New research shows competition between stem cells of different species
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University of Texas Southwestern Medical Center, Dallas, the First Affiliated Hospital of Sun Yat-sen University, China, etc. Researchers from the institution collaborated to complete the study.
Cell competition is considered to be a selection mechanism that guarantees normal development and tissue stability. However, there has been a lack of research on cell competition among different species in the early stages of development. According to the team, they first discovered in their experiments that human and mouse stem cells have different competition states at specific developmental stages, and revealed related mechanisms to solve the problem of low efficiency of human-mouse chimeric embryos that has been plagued by the scientific community. A breakthrough has been found. The breakthrough of this difficult problem has made people look forward to the prospect of using chimeric embryos for artificial organ culture.
Based on mice and rats In the analysis of pluripotent stem cells from monkeys, macaques, cattle and humans, the team also found that at specific developmental stages, stem cells of different species have different levels of competition. This difference in competition status may be in the “evolutionary tree” of different species. The distance on the distance is related.
Wu Jun, the corresponding author of the paper and an assistant professor in the Department of Molecular Biology at the University of Texas Southwestern Medical Center, told Xinhua News Agency that the use of chimeric embryo technology to cultivate human organs in animals has great medical potential, but it is affected by different species. The limitation of incompatibility between development and overcoming the early developmental obstacles between species that are far away on the “evolutionary tree” is the key to cultivating human organs in animals. New discoveries can help solve this problem.
The co-first author of the paper, Zhongshan Dr. Zheng Canbin of the University’s First Hospital said that this research enriches the theory of cell competition. By overcoming cell competition of different species, it helps to increase the chimeric rate of human stem cells in animal embryos, and provides future use of chimeric embryo technology. The manufacture of human organs brings new hope.