2021-05-03

Studies have found that the same drugs have opposite effects on men’s and women’s memory

By yqqlm yqqlm

Studies have found that the same drugs have opposite effects on men’s and women’s memory

This is the first time that a drug has been shown to affect males And the memory of female mice has this opposite effect. The study also proved that in the process of memory formation, due to gender differences, opposite molecular mechanisms and behaviors occur. The research has been published in Nature Communications.

The research team on the transformation mechanism of fear memory led by ICREA professor and researcher Raül Andero has been studying the function of fear memory for many years to find treatments for conditions related to traumatic experiences, such as post-traumatic stress and fear disease. The research team has discovered that the Tac2 circuit located in the amygdala can be temporarily blocked by the effects of a drug they are studying. The drug, called Osanetant, can reduce the ability of male mice to recall traumatic events. In a study published now, they found that this same drug had the opposite effect in female mice, increasing their fear memory.

This opposite effect can be explained by the fact that when blocking the Tac2 pathway, the drug interacts with the neuronal receptors of two sex hormones: male testosterone and female estrogen. In addition, it has been observed that hormonal fluctuations in female mice during the estrus cycle (equivalent to a female’s menstrual cycle) change the effect of the drug on the ability to remember aversion events.

” Antonio Florido, postdoctoral researcher at INc-UAB and the first author of the article, said: “These results prove that hormones have the ability to regulate the formation of fear memories, and indicate that gender differences need to be considered when designing drug treatments for mental illness. And the hormone cycle.

In the field of neuroscience, one female study is published for every 5.5 male studies. The research on the Tac2 pathway has so far been mainly done on men.

Understanding the memory process of different genders is the key to designing treatments for phobias, especially considering that women are the people who have these types of disorders most often. Research coordinator Raül Andero said: “Some of the drugs that have been used may not have the expected effect on them. Our findings may help raise awareness of the need for gender-based research and promote basic and clinical research including women. .”

The drug studied is not new, but it is safe to use in humans. However, it has not yet been used to treat any diseases. Dr. Andero’s team is now investigating its potential use in the treatment of gender-specific phobias.

In this research conducted in collaboration with other INc-UAB research groups and the Hospital del Mar Institute of Medicine (IMIM), scientists have shown the importance of personalized medicine. “They concluded: “The mental health drugs we have today are not only used to treat memory-related diseases, but they are also not specific enough and may cause opposite effects to expectations.