2021-05-03

The world’s first imaging detector uses laser and sound to detect cancer cells

By yqqlm yqqlm

The world’s first imaging detector uses laser and sound to detect cancer cells

The fiber optic ultrasonic probe developed by the Nottingham University team is described as the world The initiative was conceived as a clinical solution to solve some of the defects of cell imaging. At present, this requires the use of large and complex scientific instruments in research laboratories, and it often involves fluorescent labels made with chemicals that pose a risk to human cells in sufficiently large doses.

Team member Dr. Salvatore La Cavera III said: “Techniques that can measure whether tumor cells have formed and deteriorated have been implemented through laboratory microscopes, but these powerful tools are cumbersome to use. They cannot be moved and cannot be used. Adapt to the patient-oriented clinical environment. “The nano-level ultrasound technology with endoscopic capabilities is expected to achieve this leap.”

The world’s first imaging detector uses laser and sound to detect cancer cells(1)

This imaging sensor has a pair of lasers, one of which is converted into high-frequency sound particles called phonons by a metal layer on the top of the fiber. These phonons are Pumped into the surrounding tissues, which scatters the sound wave, and then collides with a second laser. By analyzing these collisions, the system can visually reproduce the shape of the sound wave in motion, which can reveal the cells it passes through The useful features of the skin.

The key is that this includes the geometry and its hardness. In this way, the team compares its new tool to a doctor’s physical means to feel the abnormalities and hardness under the skin. This may be a sign of cancer. However, its ultrasound probe can produce a three-dimensional map that reveals the hardness and spatial characteristics of the structure measured at the nanometer scale, the details of which are similar to, or even more than, microscope images.

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p >The world’s first imaging detector uses laser and sound to detect cancer cells(2)

A 3D image of a model biological cell constructed with a new ultrasonic sensor (Bottom) Comparison with traditional microscope images (top)

According to scientists, this tiny imaging device can be installed on an optical fiber or integrated into traditional endoscopes. 10-20000 fiber bundles. These devices consist of thin tubes equipped with lights and cameras that can be inserted into the body to search for signs of disease. The team hopes that by combining them with their new probes, they can open up in the field of clinical diagnosis New possibilities.

The system measures specimen hardness, biocompatibility, and the potential for perfect integration with endoscopes. It also allows medical observations to enter the nanometer scale. It is unique These characteristics lay the foundation for future measurements in vivo; the ultimate goal of minimally invasive medical point diagnosis has been achieved. The team is now exploring the potential of the tool in cell and tissue imaging, but it is envisaged that it will also have applications in precision manufacturing. Value, it can be used for surface inspection and material characterization.