2021-06-03

Encephalitis caused by secondary infection can worsen Alzheimer’s cognition and memory

By yqqlm yqqlm

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Encephalitis caused by secondary infection can worsen Alzheimer’s cognition and memory

In the Journal of Alzheimer’s Association, “Alzheimer’s Disease and In this study on Dementia, mice showing the characteristics of Alzheimer’s disease were exposed to acute inflammatory events to observe its downstream effects on brain inflammation, neuronal network function, and memory.

These mice showed new changes in the output of astrocytes and microglia, and showed new cognitive impairments and disordered “brain rhythms”, which are in healthy, age-matched It did not happen in mice. These new cognitive changes are similar to acute and distressing mental disorders such as delirium, which often occurs in elderly patients.

Although it is difficult to replicate these findings in patients, the study also showed that the brain IL-1β levels of AD patients who died of acute systemic infections are elevated, which is a pro-inflammatory molecule. It is important to cause an increase in the immune response and new-onset disorders in AD mice.

Colm Cunningham, associate professor of the Trinity School of Biochemistry and Immunology and the Trinity Institute of Biomedical Sciences, led the research. He said:

“Alzheimer’s disease is the most common form of dementia, affecting more than 5% of people over the age of 60. This painful and debilitating condition brings a lot of people around the world. It’s difficult. The more we know about this disease and its development, the more opportunities we have to treat these patients. We believe that our work adds to this knowledge base in several ways. First, we show that Alzheimer’s The brain affected by the disease is more susceptible to acute inflammatory events, even if these events occur outside the brain. Putting this in the context of the slow-developing AD progression, we propose that these superfluous events are now seen in multiple cell populations. Sensitivity may contribute to the negative consequences of acute illness in elderly patients, including the onset of delirium and the acceleration of cognitive trajectories, which have been observed in patients who experience delirium before or during dementia.”