New measures against superbugs: intake of fatty acids in fish oil can reduce antibiotic resistance

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“The important thing is our research It shows that a major antibiotic resistance mechanism in cells can be negatively affected by the absorption of omega-3 dietary lipids,” said Dr. Bart Eijkelkamp, ​​a microbiologist, who leads the bacterial host adaptation research laboratory at Flinders University.

“In experiments and complementary supercomputer modeling, we found that these fatty acids in fish oil make bacteria more susceptible to various common antibiotics. The gap opened by harmful bacteria armor is a blow An important step towards the rise of superbugs that are resistant to antibiotics,” said co-author, Associate Professor Megan O’Mala of the Australian National University.

New measures against superbugs: intake of fatty acids in fish oil can reduce antibiotic resistance

The field of infectious diseases caused by bacteria such as Acinetobacter is very important. Acinetobacter baumannii is a major iatrogenic pathogen, and its antibiotic resistance has reached an unprecedented level in the world.

“With the rise of super bacteria, we have now been able to prove that greedy bacteria cannot distinguish between’good and bad’ host fatty acids and will consume all of these fatty acids during infection,” another Said co-author, Dr. Felise Adams of Flinders University. “Our research shows that fish oil fatty acids become part of the bacterial membrane, making the invading bacterial membrane more transparent and susceptible to the antibiotics used to attack it. We know that Acinetobacter baumannii is the most notorious resistant bacteria in the world. One of the multi-drug pathogens, yet how it responds to host-mediated stress is poorly understood.”

“These studies provide new insights into the potential benefits of omega-3 supplements against bacterial infections. , Especially during antibiotic treatment,” said Professor Anton Peleg, Director of the Department of Infectious Diseases at Melbourne Alfred Hospital.