2021-07-21

Research says maternal fecal transplantation may reduce the damage of antibiotics to neonatal microbiota development

By yqqlm yqqlm

Research says maternal fecal transplantation may reduce the damage of antibiotics to neonatal microbiota development

There are still many unanswered questions in the world of microbiome science puzzle. When the baby’s microbiome begins to form is one of these questions. Some studies have shown that the microbiome begins to multiply in the womb, while other studies assume that birth is an important moment of formation, mainly due to bacterial exposure from the mother’s birth canal.

A study from a Finnish research team last year showed that a fecal transplant from mother to baby can restore any microbiome damage seen in babies born by caesarean section. This new research focuses on the destruction of the infant’s microbiome by the early use of antibiotics.

“Our previous work has shown that exposing young animals to antibiotics can disrupt the microbiome, which may change age-related immunity and organ-specific inflammation, and increase the risk of immune-mediated diseases,” the research shared Author Martin Blaser explained.

The new research focuses on a specific mouse model that has been bred to have a higher risk of developing type 1 diabetes. Known as NOD (non-obese diabetic) mice, previous studies have shown that the microbiome of this animal plays a key role in regulating their diabetes risk.

The researchers exposed a group of NOD mice to antibiotics in the first few days after birth. As expected, this reduced the animal’s intestinal bacterial diversity. Then half of the mice received a fecal transplant from the mother mouse to restore the damaged microbiome.

Compared with animals that did not receive microbiome recovery, those that received fecal transplantation showed a significantly lower risk of developing diabetes. Study co-author Zhang Xuesong (transliteration) said that stool transplantation restored gene expression in several metabolic pathways that are responsible for diabetes risk.

Zhang Xuesong said: “Mice exposed to antibiotics have either too high or too low expression of index genes on the intestinal wall, but transplantation makes it almost back to the original level and restores the metabolic pathway. . We can confirm that the genome returns to normal after transplantation, just like mice have never received antibiotics.”

Such research is still in its early stages, and the next step for the team will be to try and determine the development of diabetes Specific bacteria to protect. It is also important to note that fecal transplantation is not without significant risks. Stool may contain harmful pathogens, and human trials to test this treatment will rigorously screen samples before application.