Human protein enables researchers to deliver drug treatments directly to cells

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Human protein enables researchers to deliver drug treatments directly to cells

By using proteins naturally present in the human body, this method produces fewer immune responses than similar delivery systems. The researchers found that the delivery system works effectively in cell models. They believe that further development may lead to a new class of delivery methods for a series of molecular drugs. For example, the system can be used for gene editing or replacement.

Although there are similar gene editing and replacement delivery platforms, they are inefficient compared to new technologies. A big disadvantage of existing systems is that they are randomly integrated into the cell’s genome, which stimulates the immune response. SEND can overcome the problems surrounding the current transmission system.

One of the core components of SEND is the PEG10 protein, which binds to its own mRNA in the human body to form a protective capsule around it. In this study, the researchers designed PEG10 packaging to deliver other RNA. They were able to deliver the CRISPR-Cas9 gene editing system into mouse and human cells. Once inside the cell, the editing system can edit the target gene.

Researchers pointed out in the study that there may be other RNA transmission systems in the human body that can also be used for therapeutic purposes. The protein used in this study, PEG10, is naturally present in the human body and comes from a virus-like genetic element that was integrated into our ancestors millions of years ago.