2021-08-13

Pfizer, Johnson & Johnson, Moderna, who has the highest rate of breakthrough infections?

By yqqlm yqqlm

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Pfizer, Johnson & Johnson, Moderna, who has the highest rate of breakthrough infections?

But does the probability of people having a breakthrough infection depend on the type of vaccine they receive?

To put it simply, we don’t know the exact answer, but there are some hints in the relevant data. Johnson & Johnson’s vaccine seems to have a higher rate of breakthrough infections than Pfizer and Moderna’s vaccines. It is only based on expected data from clinical trials. Some previous signs have shown that the breakthrough infection rate of Moderna vaccine is slightly lower than that of Pfizer vaccine, but this is only based on data from millions of residents in two regions, so it may not be representative of the actual situation of the entire country.

Since no vaccine is 100% effective, scientists expected that breakthrough infections would appear sooner or later when the vaccine was launched. In clinical trials, the rate of new coronavirus infections in people who were injected with Pfizer vaccine The infection rate is 0.04%, while the infection rate of the people injected with Moderna vaccine is about 0.07%, and the infection rate of people injected with Johnson & Johnson vaccine is about 0.59%.

At present, many vaccine brands have been authorized and approved. Scientists can track and analyze the true breakthrough infection rate outside of clinical trials in real life. When a breakthrough infection occurs, most people will have mild Symptoms, if the condition worsens, some patients will need to be hospitalized and even die.

However, the recent highly contagious Delta virus may increase the risk of breakthrough infection. For example, on August 6, the Centers for Disease Control and Prevention (CDC) published an article on Morbidity and Death Rate Weekly Report (MMWR), the article pointed out that from May to June this year, the number of Delta virus infection patients in Mesa County, Colorado, USA, increased sharply. area.

Researchers searched for information on the websites of the health departments of various states in the United States and found that most of the information reported on cases of breakthrough infections appeared on the websites of the state government’s health departments, in the 25 states that reported breakthrough infections. Most states did not provide data on the number of cases associated with each vaccine brand.

However, the states of Oklahoma and Washington in the United States have announced the brands of vaccines that have been injected by breakthrough infections. The Washington State Health and Health website claims that these data can provide “early signals” about the work of the vaccine. , Especially before the emergence of new virus variants, it is convenient for researchers to retrospectively analyze the virus mutation process. At the same time, the current epidemic prevention and control work has exposed some limitations: too few data sets are available, the number of people vaccinated for each vaccine is different, and the time of vaccination is different, so it is difficult to interpret these data.

Nevertheless, according to the latest data from the Washington State Health website, as of August 1 this year, more than 299,000 Washington State residents have been fully vaccinated against the new coronavirus. Among this population, nearly 151,000 are vaccinated After two doses of Pfizer vaccine, approximately 124,700 people received two doses of Moderna vaccine, and approximately 24,000 people received one dose of Johnson & Johnson vaccine.

Among the breakthrough infection cases, the vaccine brand with the highest probability of breakthrough infection is Johnson & Johnson, with 77 people, accounting for 0.32% of 24,000 vaccinators; next is Pfizer vaccine, with 308 breakthrough infection patients People, accounting for 0.2% of 151,000 vaccinators; followed by Moderna vaccine, after 124,700 people were vaccinated, 161 people had breakthrough infections, accounting for 0.13%.

In fact, the data is still very conservative, and there may be asymptomatic, mild, moderate, and severe breakthrough infections. Some asymptomatic or mildly infected people may not receive nucleic acid testing, so their infection status It will be missed, which means that this is an understated data, maybe the real data will be very shocking.

Currently, the state of Oklahoma in the United States has also reported similar data. On August 2, more than 1.5 million Oklahoma residents were fully vaccinated. About 817,000 people were vaccinated with Pfizer and 674,000 were vaccinated. Moderna vaccine, 102,000 people received Johnson & Johnson vaccine. Similarly, statistics show that patients vaccinated by Johnson & Johnson have the highest probability of breakthrough infection. 215 vaccinators tested positive for the virus, accounting for 0.21%; Pfizer vaccinated 1468 patients with breakthrough infection, accounting for 0.17%; At the same time, 831 Moderna vaccinators had breakthrough infections and tested positive for the virus, accounting for 0.12%.

These are real data from Oklahoma and Washington state, and may provide an incomplete picture of breakthrough cases in each region. However, it is not clear whether the observed pattern is representative of the entire country . Robert Darnell, an internal medicine scientist at the Rockefeller University in the United States, said that in order to accurately compare vaccine brands, especially to compare data with the widespread delta virus variants, we need more data.

Other preliminary studies have shown that Moderna vaccine provides more protection against Delta virus variants than Pfizer vaccine, which may help explain the difference in breakthrough infection rates. On August 8, the latest statistical research report showed that during the period from January to July, with the emergence of the Delta variant virus, the effectiveness of the Moderna vaccine dropped from 86% to 76%, while the effectiveness of the Pfizer vaccine dropped from 76%. Decrease to 42%.