2021-09-30

Research: canine parasites have evolved resistance to almost all drugs

By yqqlm yqqlm

Research: canine parasites have evolved resistance to almost all drugs </ P >

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p > according to new research from the University of Georgia, they have now become multi drug resistant. At present, American veterinarians rely on three types of drugs to kill hookworm, but this kind of parasite seems to be resistant to all drugs. Researchers from the University of Georgia School of veterinary medicine first reported this worrying development in 2019. A new study recently published in the International Journal of parasitology: drugs and drug resistance provides deeper insights into where the problem began and how bad it later became</ p>

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p > in this study, the researchers focused on the current and previous racing greyhound. Racing dogs are particularly conducive to the spread of this parasite because the sandy land of these facilities is an ideal breeding ground for hookworm. Due to this condition, all dogs are treated with insect repellents about every three to four weeks</ p>

Research: canine parasites have evolved resistance to almost all drugs(1) </ P >

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p > after analyzing fecal samples from the Greyhound adoption center, three veterinary clinics cooperating with the adoption group and an active dog racing field, the researchers found that parasites were very common in the breed. Hookworm disease was detected in four out of five greyhound. Ray Kaplan, the corresponding author of the study and a former professor of veterinary parasitology at the University of California, said that Greyhound that tested negative may also be infected</ p>

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p > hookworms can sometimes “hide” in tissues where they do not reproduce and lay eggs until the infection worsens and penetrates the dog’s intestines. But perhaps even more shocking, the team saw that even after treatment, dogs still had high levels of hookworm infection. This study marks the first report of a dog parasite with extensive multidrug resistance in the world</ p>

Research: canine parasites have evolved resistance to almost all drugs(2) </ P >

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p > when many dogs are infected with many parasites, such as in race dog farms and kennels, parasites have more opportunities to develop rare mutations that enable them to survive anthelmintic treatment. If anthelmintic agents are often used, the emerging drug-resistant hookworms will survive and help them pass the mutation on to their offspring</ p>

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p > with repeated treatment over time, most drug-sensitive hookworms in farms or kennels will be killed, and then drug-resistant hookworms will prevail. To complicate the problem, veterinarians usually do not test animals after treatment to ensure that hookworm has disappeared, so drug-resistant hookworm will not be noticed until dogs are seriously infected and begin to show signs of hookworm disease</ p>

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p > researchers found that almost all fecal samples were positive for this mutation, which enabled hookworm to survive the treatment of benzimidazoles, a broad-spectrum insect repellent for animals and humans. Although there is no molecular test to test the resistance to the other two drugs, other types of tests conducted by the research team show that hookworm is also resistant to these drugs</ p>

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p > “there is a very mature Greyhound adoption industry because they are lovely dogs,” Kaplan said. “I once owned one. However, with the adoption of these dogs, drug-resistant hookworm will appear in other pet dogs.” </ P >

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p > 11876f304bdb6a1 - Research: canine parasites have evolved resistance to almost all drugs </ P >

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p > a possible “hotbed” of potential drug-resistant hookworm outbreaks is also a place where many dog owners exercise animals: dog park</ p>

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p > Kaplan said: “personally, I will not take my dog to the dog park. If your dog is infected with these drug-resistant hookworm, it is no longer as simple as drug treatment. Before the emergence of new types of drugs, taking your dog to the dog park must be regarded as a dangerous activity.” </ P >

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p > the researchers pointed out that hookworm larvae live in the soil, You can also get in through the dog’s skin and claws. The mother dog can pass the parasite to her puppies through milk. In addition, hookworm can also infect humans</ p>

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p > this infection does not behave the same in humans, but after the insects penetrate the skin, they cause a red and very itchy rash when walking downstream of the skin. As the number of drug-resistant hookworms increases, they will also pose a risk to humans</ p>

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p > in the past, doctors used to treat patients with an ointment containing insect repellent and corticosteroids. “Unfortunately, this does not work for these drug-resistant hookworms,” Kaplan said, but hopes were not completely dashed</ p>

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p > in another recent study, Kaplan and Pablo Jimenez Castro, the lead author of the study and a recent doctoral graduate of Kaplan laboratory, found that these hookworms resistant to multiple drugs do seem to be sensitive to emodepside, which is currently only approved for cats in the United States</ p>

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p > the American Association of veterinary parasitologists recently established a working mouth to solve the problem of drug resistance of hookworm in dogs</ p>