2021-09-13

Study: Vitamin E, CoQ10 and GSH supplements can reverse heart damage caused by cancer

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Tumors in mice and fruit flies can cause different degrees of cardiac dysfunction, especially the heart blood supply Decline in capacity.

Adding specific types of antioxidants to the food eaten by tumor-bearing fruit flies can reverse the damage to the heart-this finding suggests that the damage caused by free radicals may be cancer and heart dysfunction the relationship between.

“Cancer becomes a systemic disease. Not just a tumor is doing one thing,” Shubha, assistant professor of pharmacology at Ohio Northern University and part-time teacher of physiology and cell biology at Ohio State University Gururaja Rao said.

Most known cancers are related to heart damage, the toxic effects of chemotherapy and the muscle atrophy often experienced by cancer patients.

This is the first study to use genetic models to study the direct impact of cancer on cardiac dysfunction. Researchers have discovered that different cancer-related genes affect the heart in different ways-a sign that one day genetic information may guide cardioprotective treatment decisions for cancer patients.

One of the lead authors of the study, Harpreet Singh, associate professor of physiology and cell biology at Ohio State University, said: “This shows that if you know the genes that cause cancer or the abnormal genes of certain cancers, you can Tailor-made treatments. Most importantly, we want to make clinicians realize that when cancer is first discovered, long before muscle atrophy or chemotherapy starts, other organs have received the information and are affected.”

The paper of this research has been published on “Antioxidants”.

Study: Vitamin E, CoQ10 and GSH supplements can reverse heart damage caused by cancer

It is estimated that 50% to 80% of Cancer patients suffer from cachexia. Cachexia can induce muscle atrophy that can lead to heart failure, and radiotherapy and chemotherapy can cause toxicity-related damage to the myocardium.

However, new research shows that heart problems may occur before cancer treatment or muscle atrophy occurs. The Ohio State University research team pointed out that a recent study published in the Journal of The America Heart Association stated that abnormalities in the heart tissue and heart function of human cancer patients were found before cancer treatment started.

In this new study, researchers at Ohio State University injected breast cancer cells into the mammary glands of mice and measured the animal’s heart function four weeks later. As a result, they found that the left ventricular ejection fraction and shortening fraction, two indicators of heart pumping volume, decreased by about 20% and 22%, respectively.

In Drosophila, the research team overexpresses oncogenes, which triggers the development of eye tumors in Drosophila. The scientists observed a significant decrease in ejection fraction and shortening fraction—similar to those observed in mice with tumors—and an increase in the heart rate of flies with tumors.

Researchers found that compared with the control group, the production rate and total amount of free radicals in fruit flies with tumors increased. Compared with the control group, the active oxygen generation rate of tumor mice was also significantly higher.

In order to test whether supplements can reverse tumor-related heart damage, the researchers added four antioxidants to the food of fruit flies for seven consecutive days: glutathione (GSH), vitamin E, CoQ10 Or vitamin C.

The results show that, except for vitamin C, all vitamins can restore the heart function of fruit flies to normal levels.

Rao said: “We don’t yet know why one antioxidant is effective against another.” She also added that fruit flies eat antioxidants in food, but the researchers also There is no clear information about the dosage of antioxidants.

Tao and Singh also emphasized that reactive oxygen species are only a confirmed mechanism of tumor-related heart damage, and there is still much to be learned about how antioxidants are suitable for treatment options.

Although this study focused on an oncogene to study the mechanism of heart damage in fruit flies, the researchers initially tested the effects of several oncogenes in fruit flies. The degree to which the function of the heart is affected and the degree to which it affects the heart vary from gene to gene. Rao plans to continue genetic research on fruit flies and test the effects of antioxidants on the heart of tumor-bearing mice.

Currently, Singh is working with clinicians at Ohio State University and other institutions to collect blood samples from cancer patients with heart failure. “The signal is transmitted from the tumor to the heart, and the tissue that connects these parts is blood-so the question is, do reactive oxygen species flow in the blood?” He said, “In clinical terms, our first task is to find different carcinogenic pathways and The correlation between heart failure. Secondly, we want to know what the information is and whether we can prescribe antioxidants.”