2021-10-13

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health

By yqqlm yqqlm

<img src=’https://static.cnbetacdn.com/article/2021/1012/e7e8294d21f570c.jpgClare Bryant, senior author of the study and professor of veterinary medicine at Cambridge University, said they found that carnivores lacked a complete set of inflammatory genes. Affected by this immune system defect, they are likely to become asymptomatic carriers of pathogenic pathogens

specifically, three genes essential to intestinal health in carnivores have failed. If they did, they could have produced protein complexes called “inflammasomes” to activate the inflammatory response and repel pathogens

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health

study figure – 1: the activity of the fusion protein is significantly limited in infected cells

the researchers pointed out that the high protein carnivorous diet is considered to have antibacterial properties and can make up for the loss of carnivore related immune pathways, which means that any intestinal infection will be excreted due to diarrhea

on the other hand, Clare Bryant added: this immune deficiency also means that we may find zoonotic pathogens in these animals that we have not seen before – which was completely unexpected

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health(1)

research figure – 2: the fusion protein cannot activate the atypical inflammatory body pathway in vivo

many animals, including mink, dog and cat, are considered to be the largest carriers of zoonotic pathogens. COVID-19, which caused the COVID-19 pandemic, is also suspected by many researchers from wild animal. p>

in carnivores, three genes seem to be in the process of complete loss – DNA still exists, but there is no corresponding expression, which means that they have become “pseudogenes” and can not play a role

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health(2)

research figure – 3: NLR gene bank and NLRP3 dependent inflammatory corpuscle pathway are severely damaged in carnivores

after unique mutations in three key genes crucial to the intestine, This leads to the fusion of two proteins called caspases and changes their function, eventually making them no longer respond to some pathogens in animals

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health(3)

study figure – 4: mediated infection of carnivorous cells in the middle and late stages of cell withering and apoptosis   IL-1 β Clare Bryant said: “when you breed a large number of carnivores such as minks, they may carry pathogens such as sars-cov-2 and mutate. Then because their immune system is not activated, they may eventually be sensed to humans”

Breeding carnivores or becoming a hidden “disease bank” pose a potential threat to human health(4)

study figure – 5: inflammatory body activity induces pore formation, but it is not related to cell lysis in Carnivora

even so, the researchers stressed that there was no need to worry about covid-19 transmission by cats and dogs. After all, there is no strong evidence that these domestic pets carry or transmit COVID-19. p>

only when a large number of predators gather together, it is possible for a repository containing a large number of pathogens to establish a connection and trigger potential variation