2021-10-31

NIAID scientists followed the two men to control HIV after stopping antiretroviral therapy

By yqqlm yqqlm

Visit: Alibaba cloud 11.11 shangyun Carnival activity hall 2021 tmall double 11 red envelope Jingdong double 11 “top Beijing Post” collection entrance

3b1b9664a0f2046 - NIAID scientists followed the two men to control HIV after stopping antiretroviral therapy

this study was published in the journal Nature Medicine on October 28, 2021, Led by Dr. Tae wook Chun, head of the HIV immunology group of the National Institute of allergy and infectious diseases (NIAID) immunomodulation laboratory under the National Institutes of health, and Anthony S. Fauci, M.D., director of NIAID and director of immunomodulation laboratory</ P>

the study involved two adult AIDS patients who began receiving antiretroviral therapy shortly after the infection and continued treatment for more than six years, successfully inhibiting HIV. These people then joined an HIV clinical trial and stopped antiretroviral treatment under medical supervision. The research team followed one of them for four years and the other for more than five years, about every two to three weeks

the researchers monitored the time and scale of virus rebound in each participant, that is, when the number of HIV in their blood became detectable. One participant suppressed the virus through intermittent rebound for nearly 3.5 years, when he began taking suboptimal antiretroviral drugs, but did not tell the research team. Another participant almost completely inhibited HIV for nearly four years. At this time, because he was infected with different HIV strains, the virus rebounded sharply. This phenomenon is called “super infection”

in the first participant, scientists found a high level of HIV specific immune cells, called CD8 + T cells, which can kill virus infected cells, indicating that different control mechanisms work in everyone. The researchers also found that the second participant had a weak response to HIV CD8 + T cells, but his neutralizing antibody response was very strong throughout the follow-up period until the virus suddenly rebounded. According to scientists, this suggests that neutralizing antibodies may play an important role in promoting the person’s near complete HIV inhibition until he is newly infected with a different virus strain

the researchers stressed that in order to avoid the emergence of viral drug resistance and prevent the potential misunderstanding of scientific data in such studies, it is very important to carry out routine antiretroviral drug testing for HIV patients who have stopped treatment for a long time. In addition, the researchers found that HIV super infection is a potential reason for the sudden virological breakthrough of HIV infected people who stop treatment, especially when the breakthrough occurs after long-term virus inhibition