2021-10-17

Research: a coronavirus vaccine may provide broad immunity to other coronaviruses

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,” before our research, it was unclear if you could get cross protection with other COVID-19 when you came into contact with a COVID-19. We proved this, “the lead author of this study. Pablo Penaloza MacMaster, assistant professor of Microbiology Immunology at Northwestern University’s Feinberg School of medicine</ The three main families of COVID-19 that cause p>

disease are

Embecovirus, including OC43, which is usually the arch criminal of cold. p>

merbecovirus, a virus that causes Middle East respiratory syndrome (mers), was first reported in 2012

the vaccine shows cross protective immunity

the study found that the plasma of human vaccinated with sars-cov-2 vaccine produced antibodies (which may provide protection) with cross reaction to sars-cov-1 and common cold coronavirus (OC43). The study also found that mice immunized with sars-cov-1 vaccine developed in 2004 had an immune response to protect them from intranasal exposure to sars-cov-2. Finally, the study found that previous coronavirus infection can protect them from subsequent infection by other coronaviruses</ The p>

study found that immunization with COVID-19 vaccine and later exposure to common cold coronavirus (HCoV-OC43, different from SARS strain) partly protected the common cold, but with much less protection. The scientists explained that the reason is that sars-cov-1 and sars-cov-2 are genetically similar – like each other’s cousins – while the common cold coronavirus is more different from sars-cov-2

“as long as the correlation of coronavirus is greater than 70%, mice will be protected,” Penaloza MacMaster said. “If they are exposed to very different coronavirus families, the vaccine may bring less protection.”

is there a universal coronavirus vaccine

according to the researchers, given the differences of each coronavirus family (sarbecovirus, embecovirus and merbecovirus), the answer is “probably not”. But they say there may be a way to develop a vaccine for each coronavirus family

Penaloza MacMaster said: “Our research has helped us reassess the concept of universal coronavirus vaccine. Although probably not, we may eventually provide a universal vaccine for every major coronavirus family, such as universal Sarbecovirus vaccine for SARS-CoV-1, SARS-CoV-2 and other SARS related coronavirus drugs, or for HCoV-OC43 and HKU1 that cause common cold. Embecovirus. ”

in this study, Penaloza-MacMaster assessed the human immune response to SARS-CoV-2 vaccine and the COVID-19 patients admitted to the northwest Memorial Hospital in collaboration with Finn Berg’s neuroinfectious diseases and global neurology director Dr. Igor Koralnik and Finn Berg’s Neurology postdoctoral research assistant Lavanya Visvabharathy. “We found that these people developed an antibody response to the common cold coronavirus hcov-oc43,” Penaloza MacMaster said. “We are now measuring the duration of this cross protection.”

‘s many years of HIV research led to the discovery of

. Before the COVID-19 pandemic, Penaloza-MacMaster had studied the HIV vaccine for ten years. His understanding of the variation in the HIV virus led him to question the cross reactivity of the coronavirus vaccine. “One reason we don’t have an effective HIV vaccine is that it’s difficult to produce cross reactive antibodies. Therefore, we thought,’what if we solve the problem of coronavirus variability in the way of HIV vaccine development, which is very important for developing a universal coronavirus vaccine?'”