2021-10-14

The new study of nature confirms that the mRNA vaccine is effective for 16 variants of COVID-19, such as delta.

By yqqlm yqqlm

Recently, the top academic journal Nature published an important paper online in the form of “accelerated article preview” to answer this question

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Yale University’s research team tested blood samples from vaccinations, and confirmed that two existing mRNA vaccines could enhance immune system response to infection and prevent more than a dozen new crown virus variants including the delta strain. The results also showed that people infected with COVID-19 before vaccination showed a stronger immune response to various variant strains. p>

Professor Akiko Iwasaki, an immunologist at Yale University, and Professor Nathan grubaugh and Professor Saad Omer, epidemiologists, led the study. The team collected hundreds of blood samples from 40 medical and nursing staff at Yale New Haven Hospital, including before vaccination, during the vaccination of two doses of mRNA new crown vaccine and a period of time after vaccination

The new study of nature confirms that the mRNA vaccine is effective for 16 variants of COVID-19, such as delta.

then, the researchers evaluated these blood samples using live viruses of 16 new crown variant strains that have been found and isolated. Because different mutant strains accumulate different mutations, some can enhance transmission, and some can produce immune escape, the researchers measured and compared the antibody neutralization ability and T cell immune response of blood samples to each mutant strain

although the intensity of immune response varies from person to person and from variant strain to variant strain, overall, researchers saw that the immune response increased after vaccination in the samples provided by all volunteers. The titer of neutralizing antibody against COVID-19 spike protein and its receptor binding domain (RBD) reached a peak on the 7 day after inoculation of second doses. p>

the researchers also comprehensively analyzed the immune escape of various mutant viruses. Among them, the mutant strains with e484k and n501y / T mutations in spike protein are the most significant to reduce the neutralization ability, which means that the mutations at these key sites are very important to weaken the protection of the vaccine. This variant of COVID-19 includes the first variant of Beta found in South Africa (B.1.351) and the earliest Gamma variant (P.1) found in Brazil. p>

The new study of nature confirms that the mRNA vaccine is effective for 16 variants of COVID-19, such as delta.(1)

Professor Akiko Iwasaki pointed out that the breakthrough infection caused by the widely popular delta variant is unlikely to be caused by the failure of the vaccine to induce immune response, but more likely due to the highly infectious characteristics of the delta strain, Broke through the resistance of the immune system

Professor Nathan grubaugh added, “because the delta variant is more infectious than the early variant, its high transmission ability can better explain the infection after vaccination than its immune escape ability.”

in this study, the scientists also compared the volunteers infected with the new crown before vaccination with the uninfected volunteers. They found that infected people had a stronger immune response, and the antibody titer after vaccination was significantly higher than that of uninfected people. “Recovering from the initial infection is equivalent to the first shot of vaccine,” Professor Iwasaki explained. On the other hand, it also shows that for vaccination, strengthening needle plays an important role in improving antibody and T cell immune response. It is a relevant strategy to alleviate the impact of new variants on antibody neutralization activity in the future</ P>

has made many predictions for the evolution of the new crown virus. Scientists, for example, Dr. Roberto Burioni, a famous Italy virologist, made a preconceived idea of the future of the new crown virus. The most optimistic possibility is that the new crown virus will not be able to completely destroy the vaccine if it advances any more. The current research results bring hope for this optimistic future