It was found that cross contact with harmless other coronaviruses can improve immunity to covid-19

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89349c618385d63 - It was found that cross contact with harmless other coronaviruses can improve immunity to covid-19

in their study, the researchers used a specially developed test method to analyze the antibody levels against the other four human coronaviruses in 825 serum samples before the emergence of sars-cov-2. They also examined 389 samples of donors infected with sars-cov-2. Combining these analyses with computer-based models enabled the research team to accurately predict the degree of binding and neutralization of antibodies to invading viruses

cross reactivity reduces the severity of infection

researchers can demonstrate that people infected with sars-cov-2 have lower antibody levels to the coronavirus that causes the common cold than uninfected people. In addition, people with high levels of antibodies to harmless coronavirus are less likely to be hospitalized after infection with sars-cov-2. “Our research shows that a strong antibody response to human coronavirus will increase the antibody level against sars-cov-2. Therefore, people who are immune to harmless coronavirus can better protect themselves from severe sars-cov-2 infection,” tekola said. This type of immune response is called cross reaction. It also occurs in T cell response, which is an additional line of the immune system against infection

It was found that cross contact with harmless other coronaviruses can improve immunity to covid-19

people can fully protect sars-cov-2 only after recovering from infection or receiving effective vaccination. At this time, the antibody level against the virus is still very high. Over time, these levels decline and infection is no longer prevented, but immunological memory quickly reactivates the body’s defense system, producing antibodies and T cell defense. “Of course, the immune response against sars-cov-2 initiated by memory cells is much more effective than the cross reaction. But even if the protection is not absolute, the cross reaction immune response will shorten the infection time and reduce its severity. This is achieved through vaccination, but it is much more efficient,” trkola said

it is not known whether this cross reactivity also plays a role in the opposite direction. For example, whether immunity against sars-cov-2 obtained by vaccination can also provide protection against other human coronaviruses still needs to be clarified. “If the immunity of sars-cov-2 can also provide some degree of protection against infection with other coronaviruses, we will take an important step towards achieving comprehensive protection against other coronaviruses, including any new variants,” the virologist explained. This idea is also supported by the fact that cross reactivity protection is based not only on antibodies, but also probably on T cells