Research on the sequelae of the new crown of the Chinese team: there are still problems such as shortness of breath and depression in the past year after discharge
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in addition, 56.7% of non critical patients showed abnormal pulmonary CT, including ground glass opacity, bronchiectasis, nodules, fibrosis, etc
- <img src=’https://static.cnbetacdn.com/article/2021/1125/97086949173de0a.pngChina China novel coronavirus pneumonia published in the journal novel coronavirus pneumonia: “assessment of sequela after 1 years’ diagnosis of new crown pneumonia”, published in Wuhan Union Hospital’s research group published in Chinese medicine frontiers on, 23, />
“the sequela of new crown pneumonia diagnosed after 1 years”. The long-term effects of novel coronavirus pneumonia on non critically ill patients were studied. P>
novel coronavirus pneumonia discharged from Wuhan Union Hospital and shelter hospital was recruited between January 29, 2020 and April 1, 2020. A follow-up study was conducted between November 23, 2020 and January 11, 2021.
the average age of 120 discharged patients was 51.6 ± 10.8 years. Among them, 104 (86.7%) discharged patients were non severe cases and 16 (13.3%) were severe cases. 49 (40.8%) were male. The shortest hospitalization time was 18 days, the longest was 33.8 days, and the median hospitalization time was 25.5 days. The median time from discharge to follow-up was 284.5 days (the shortest was 270 days, the longest was 309 days). The median time from diagnosis to follow-up was 314.5 days (the shortest is 296 days and the longest is 338 days).
all discharged patients participated in a series of questionnaires to evaluate their symptoms, quality of life and psychological status. At the same time, pulmonary function examination, chest CT examination and 6-minute walking test (6MWT) were performed Blood routine examination, liver and kidney function examination, fasting blood glucose examination, blood lipid examination and immunoglobulin G antibody examination.
the study found that nearly one third of non severe cases had symptoms of sleep difficulty, shortness of breath, fatigue and joint pain, which were the most common sequelae. Among them, 52 cases had sleep difficulty, accounting for 43.3%, 49 cases had shortness of breath, accounting for 40.8% and 43 cases had fatigue , accounting for 35.8%, 39 cases of joint pain, accounting for 32.5%.
the researchers also performed lung CT examination on 97 discharged patients, of which up to 55 discharged patients (56.7%), including 47 non severe patients and 8 severe rehabilitation patients, had impaired lung function and abnormal CT findings. Among them, the most common abnormal CT manifestation was nodule (55.7%), followed by linear shadow (47.4%), fibrosis (17.5%), ground glass shadow (16.5%) and bronchiectasis (14.4%) 。
however, the article also mentioned that in this study, the volume of bilateral lung lesions in discharged patients was significantly smaller than that in the previous study at the time of 6 months of symptoms. This shows that although some patients have abnormal imaging findings, the injury intensity is small and the lesions are small The novel coronavirus pneumonia has been resolved.
has previously conducted a 15 year follow-up study on SARS, which shows that the pulmonary interstitial changes and lung function decline caused by SARS can be successfully treated and can be recovered within 2 years. However, whether pulmonary function can be recovered for new crown pneumonia remains to be further studied.
liver and kidney function, a few discharged patients with liver and kidney Abnormal function, such as transaminase (ALT) Novel coronavirus pneumonia is not a cause of liver and kidney dysfunction. However, long-term follow-up studies are still needed.
, it is also worth noting that psychological problems of discharged patients can not be ignored. A considerable proportion of discharged patients have anxiety and depression. Hamilton Anxiety Scale and suppression are the main reasons. According to the depression scale, 50 (41.7%) patients had anxiety symptoms and 45 (37.5%) patients had depression symptoms. In non severe cases, 41 (39.4%) patients had anxiety symptoms and 39 (37.5%) Novel coronavirus pneumonia was found in the patients.
concluded that even in non critical cases, there were still multiple system problems in the discharged patients after the diagnosis of new crown pneumonia for nearly 1 years. Further investigation is needed.
repeatedly reported that the world was concerned about the sequelae of the disease. In August, the journal Nature published a title entitled “the disease”. Long term effects of more than 50 new crowns: a systematic review. This study by the US and Mexico teams showed that 80% of infected patients had one or more long-term symptoms and a total of 55 possible sequelae. Among them, the most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%) and dyspnea (24%) , olfactory failure (21%), cough (19%) Lung CT abnormalities are also common. 35% of patients still have abnormalities 60 to 100 days after the first lung CT scan. In addition, about 10% of discharged patients have symptoms such as chest pain, nausea, memory loss and tinnitus.
for the possible sequelae of the new crown, on May 13 this year, China’s Health Commission, the Ministry of civil affairs and other four departments jointly formulated “Novel coronavirus pneumonia discharged patients’ main dysfunction rehabilitation program”, standardized respiratory function, cardiac function, physical function, psychological function and activities of daily living,
assessment and rehabilitation training methods.