2021-11-19

The newly designed chemical reaction leads to a more efficient method for producing Grignard reagent

By yqqlm yqqlm

Visit: the reactants, metal magnesium and organic halides in the activity Hall of Alibaba cloud’s 11.11 shangyun Carnival are loaded into a metal chamber together with a stainless steel ball. In a key step, a small amount of organic solvent – about one tenth of the amount used in traditional methods – is added to the solid reactant. Then, the laboratory rotates for one hour to make the ball roll and hit the solid reactants to help them fully mix and react to form a paste Grignard reagent

The newly designed chemical reaction leads to a more efficient method for producing Grignard reagent

the traditional method of synthesizing Grignard reagent by reacting magnesium with organic halide in organic solvent. This method has been used for 120 years. The newly developed method of synthesizing Grignard reagent by mixing reactants in a ball mill has the least amount of organic solvent. This method can be used in ambient air to achieve a wide range of organic reactions with little solvent

researchers have even successfully used organic halides with poor solubility in organic solvents to produce new Grignard reagents, which can not be manufactured by conventional methods. Avoiding the large use of organic solvents enables researchers to overcome the solubility problem, which opens up a new way for the new reaction of Grignard reagent prepared from insoluble compounds, not to mention the significant reduction of hazardous waste

The newly designed chemical reaction leads to a more efficient method for producing Grignard reagent(1)

in addition, when less organic solvents are used, it is more difficult for water or oxygen to affect Grignard reagent. This means that there is no need to remove water and oxygen from the surrounding air, making the process easier and cheaper. Given the potential economic and environmental benefits, this discovery may have a significant impact on the chemical industry

The newly designed chemical reaction leads to a more efficient method for producing Grignard reagent(2)

Professor Hengyi ITO (left) and associate professor Haoer Kubota of the research team of Hokkaido University and Institute of chemical reaction design and discovery (icredd)

“with the increasing demand for solving environmental problems and reducing carbon dioxide emissions, it is very important to develop chemical reactions that do not need organic solvents,” commented associate professor Kubota Haoer. “Grignard reagent is the most famous and commonly used reagent in industry, so our work can fundamentally change the large-scale production mode of a large number of chemicals, so as to greatly reduce the impact on the environment.”