2021-11-13

The study says antibodies produced by people over the age of 50 naturally infected with covid-19 provide a greater degree of protection

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e452 kfnaptu9024468 - The study says antibodies produced by people over the age of 50 naturally infected with covid-19 provide a greater degree of protection

in their recent study published in the scientific report, they observed that the antibody levels of those vaccinated with Pfizer biontech or AstraZeneca vaccine were significantly higher than those infected. These antibodies are also effective against the delta variant, which did not exist in Quebec at the time of sample collection in 2020

Masson, a biomedical instrument expert, and Pelletier, a protein chemistry expert, are interested in an understudied group: those infected with sars-cov-2 but not hospitalized due to infection

32 non hospitalized Canadian adults with positive covid-19

Laval University Hospital Center recruited 32 non hospitalized Canadian adults with positive covid-19 14 to 21 days after diagnosis by PCR. This is in 2020, before the beta, Delta and gamma variants appear

Masson said: “every infected person produces antibodies, but the elderly produce more antibodies than adults under the age of 50. In addition, the antibodies still exist in their blood 16 weeks after their diagnosis”

the study found that the antibodies produced after infection with the original strain also responded to the subsequent sars-cov-2 variants, namely beta (South Africa), Delta (India) and gamma (Brazil), but to a lesser extent: a reduction of 30% to 50%

The study says antibodies produced by people over the age of 50 naturally infected with covid-19 provide a greater degree of protection

surprising response to delta variants

“but the most surprising result is that antibodies produced by naturally infected people aged 50 and over provide a greater degree of protection than antibodies produced by adults under 50,” Pelletier said

he added: “this was determined by measuring the ability of the antibody to inhibit the interaction between delta variant spike protein and ACE-2 receptor in human cells. This is the way we were infected. We did not observe the same phenomenon in other variants.”

compared with non vaccinated people, when people with mild covid were vaccinated, Their antibody levels will double because they have been infected with the virus. Their antibodies can also better prevent the interaction of spike protein-ace-2

“but more interestingly,” Masson said, “we have a sample from a population younger than 49 years old. Their infection does not produce antibodies to inhibit spike-ace-2 interaction, which is different from vaccination. This shows that in people previously infected with the original strain, vaccination increases the protection against delta variant.”

both scientists believe that more research should be carried out to determine the best combination to maintain the most effective antibody response level for all virus variants