2021-11-28

Using fat to help lose weight Chinese scientists find a switch to turn fat into friends

By yqqlm yqqlm

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! Long term high-fat diet, easy to increase the burden of intestinal tract

of course, the “good” fat here is not the fat around your stomach. Neither subcutaneous fat nor visceral fat can help you consume energy. What really does this is the brown fat mainly hiding in the glands of the scapula. Brown adipose tissue has a large number of mitochondria, which play a role in heat production

because of this peculiar property, brown fat and the subsequent discovery of beige fat (another adipocyte with thermogenic effect) soon attracted attention. A large number of studies hope to reveal the mechanism of brown fat and find ways to make the body produce more brown fat

in this series of studies, there is always a blank area, that is, the effect of cytokines on brown fat. This week, a study published in the journal Nature revealed the key mechanism. Professor Yin Zhinan, professor and professor of biomedical Transformation Research Institute of Jinan University, has found that a cell factor can promote browning and thermogenesis of adipocytes. This finding is expected to provide new targets for the treatment of obesity and type 2 diabetes. p>

Using fat to help lose weight Chinese scientists find a switch to turn fat into friends

in order to find cytokines related to obesity, the research team first screened cytokines with significantly decreased expression from the serum of obese people, including interleukin-27 (IL-27). Previous genomic studies have also pointed out that the nucleotide sequence encoding IL-27 is associated with body mass index and insulin resistance. On the other hand, the level of IL-27 in patients increased significantly after weight loss surgery and weight loss. This series of phenomena show that IL-27 seems to be closely related to the process of obesity

of course, such a relationship is only the starting point of research. To verify the role of IL-27 in this process, the research team constructed genetically engineered mice that knocked out the IL-27 receptor. After providing a high-fat diet, they found that these genetically engineered mice were more likely to be obese and had more severe glucose intolerance and insulin resistance than normal mice in the control group

therefore, the relationship between IL-27 and obesity has been confirmed. So, how does this cytokine affect the metabolic process

the next mouse experiment gives the answer. When food intake remained normal, the energy consumption of these IL-27 receptor deficient mice also decreased significantly. In addition, these mice were less resistant to the cold environment, that is, their process of generating heat through energy consumption was inhibited

in addition, the level of uncoupling protein 1 (UCP1) in genetically engineered mice decreased sharply whether fed high-fat or normal food, and UCP1 is an essential mitochondrial protein in the thermogenesis of brown and beige fat; UCP1 levels also recovered after re injection of IL-27. These phenomena show that IL-27 affects the metabolism of the body by promoting the thermogenic process of brown and beige fat

Using fat to help lose weight Chinese scientists find a switch to turn fat into friends(1)

this study also subverts a traditional understanding of cytokines. Using mice that specifically knocked out the IL-27 receptor in adipocytes, they found that IL-27 could directly act on adipocytes, promote the browning of white adipocytes and the thermogenesis of brown or beige adipocytes. This is also the first time that this cytokine can directly act on adipocytes, breaking the inherent view of “IL-27 specifically targeting immune cells”

so far, the signal pathway of IL-27 affecting the thermogenesis of brown and beige fat has been revealed. Can this pathway become a therapeutic target to help treat obesity and other metabolic diseases? This study preliminarily verified its potential in mouse experiments: obese mice injected with IL-27 significantly lost weight and improved sensitivity to insulin signal

for the significance of this study, the research team said that with the increasing proportion of overweight and obese people in the world year by year, it is particularly urgent to find new therapeutic targets, especially molecules directly targeting adipocytes. This study reveals the important role of IL-27 and provides new targets and potential drugs for the treatment of obesity and related metabolic diseases. As a normally expressed molecule in vivo, IL-27 has good safety, so it has great clinical application potential and market value

the paper was published in the journal Nature under the title of “IL-27 signaling promotes adpocyte thermogenesis and energy expenditure”. Professor Yin Zhinan is the last corresponding author of the work, and Professor Richard Flavell of Yale University, associate researcher Yang Hengwen of biomedical Transformation Research Institute of Medical Department of Jinan University and Professor Lu Ligong of affiliated Zhuhai People’s hospital are the co corresponding authors of the paper. Postdoctoral Wang Qian and Li Dehai of Zhuhai People’s Hospital Affiliated to Jinan University, associate researcher Cao Guangchao of biomedical Transformation Research Institute of Medical Department of Jinan University and Associate Professor Shi Qiping of the First Affiliated Hospital of Jinan University are the co first authors